Si bien en la filosofía de las ciencias ya se han explorado algunos ejemplos provenientes de la bioquímica como casos de estudio, la filosofía de la bioquímica es una subdisciplina naciente. En este artículo estudiaremos dos problemas filosóficos de relevancia contemporánea en esta ciencia. Por un lado, examinaremos las bases epistemológicas del problema del plegamiento de proteínas. En particular lo relacionado con la predicción de la estructura tridimensional de las proteínas a partir de su secuencia, asunto que ha dado mucho (...) que hablar debido a los nuevos avances utilizando deep learning. Por otro lado, exploraremos el problema in-vitro/in-vivo y, más generalmente, el problema de la extrapolación en las ciencias biológicas. Finalmente, a partir de las consecuencias de ambos temas consideraremos algunas reflexiones filosóficas generales acerca del reduccionismo, el pluralismo y el lugar de la bioquímica en las ciencias biológicas. Palabras clave: Bioquímica, Plegamiento de proteínas, In-vitro/in-vivo, Pluralismo, Reduccionismo. (shrink)

The protein folding problem is one of the foundational problems of biochemistry and it is still considered unsolved. It basically consists of two main questions: what are the factors determining the stability of the protein’s native structure and how does the protein acquire it starting from an unfolded state. Since its first formulation, two main explanatory approaches have dominated the field of protein folding research: a thermodynamic approach focused on energetic features and a kinetic approach focused on the temporal development (...) of protein chains and structural considerations. Although these two approaches are tightly intertwined in biochemical practice and largely agree on which are the parts and activities in which the phenomenon under study should be decomposed to, there nevertheless exist important contrasts that have had repercussions on the development of the field and still engender vigorous debate. We shall analyse the historical development of the field and crucial aspects of current scientific debates. On this basis, we argue that the main sources of disagreement centre on the causal interpretation of thermodynamic and kinetic explanations, on the explanatory relevance assigned to different features of the phenomena under study and on the status of the ontological assumptions concerning the entities under study. (shrink)

Resumen: El presente trabajo intenta analizar los elementos críticos a la base de aquella suerte de prescripción que Edward Said formulara a los intelectuales bajo la célebre consigna de “decir las verdades al poder”, esto es, de interpelar públicamente al poder -político, económico, religioso, militar- frente a toda evidencia de injusticia, inconsistencia o turbia manipulación en su operar. En tanto tal, y a partir de nuestra lectura de Said, delimitamos cinco dilemas que el intelectual ha de resolver, en tanto requisitos (...) para decir las verdades al poder: orientación intramundana versus extramundana, rol profético versus sacerdotal, libertad universalista versus organicidad, racionalidad sustantiva versus instrumental y arrojo versus temor. Se comentan las implicaciones de estos dilemas a la luz de los desafíos y oportunidades que las sociedades contemporáneas -en particular, las latinoamericanas- presentan para el rol del intelectual.: This work analyzes the critical foundations of that quasi-rule posed by Edward Said to intellectuals through the famous motto “speaking truth to power”, that is, of publicly interpellating to power -political, economic, religious, military- whenever its exercise may involve injustice, inconsistency or underhanded manipulation. So, according to our interpretation of Said’s work, we identify five dilemmas the intellectual should resolve in order to be able to speak truth to power: a worldliness orientation versus an otherworldliness one, a prophetic role versus a priestly one, universalist freedom versus organic compromise, a substantive rationality versus an instrumental one, and courage versus fear. Involvements of these dilemmas are discussed according to the challenges and opportunities posed by current societies -in particular, the Latin American ones- to the intellectual’s role. (shrink)

Resumen: La teoría de probabilidad rara vez diferencia su concepto de su determinabilidad cuantitativa. Para definir su objeto, ésta comienza por la exposición abstracta de la probabilidad y sus determinaciones o bien referidas a la esfera del ser, o bien a la esfera del pensar. Este estudio pretende, siguiendo el automovimiento de estas determinaciones en la Lógica, criticar la limitación de ambas proposiciones y presentar una concepción especulativa del fenómeno probabilístico.

One of the foundational problems of biochemistry concerns the conceptualisation of the relationship between the composition, structure and function of macromolecules like proteins. Part of the recent philosophical literature displays a reductionist bias, that is, the endorsement of a form of microstructuralism mirroring an out-dated biochemical conceptualisation. We shall argue that such microstructuralist approaches are ultimately committed to a potentialist form of micro-predeterminism whereby the macrostructure and function of proteins is accounted for solely in terms of the intrinsic properties and (...) potentialities of the components of the primary structure as if they were self-contained or essentially immutable entities. We shall instead suggest that a conceptualisation of the relationship between proteins’ composition, structure and function consistent with contemporary biochemical practice should account also for the causal role of the cellular, organismal and environmental relations in protein development. The analysis of the folding process we propose suggests that microstructure-laden reductionist approaches are ontologically indefensible. Rather than a potentialist form of micro-predeterminism, our analysis ultimately supports a relational-construction-based view of protein development and potentialities formation, which requires an indispensable analysis of the dynamical interplay between the micro-level of the parts and the macro-level of the relational structures of their systems. (shrink)

This research presents a model of Emotional Codes (EC) that influence the processes of choice, decision and action in clients. The model represents a sequence of steps to follow to identify the EC. (i) Identify the problem. (ii) Recognize the emotion (how) see Table 3. (iii) Identify the reason. (because); and (iv) Identify the emotional code (What) see Table 2. In addition, results obtained from theses and articles that demonstrate the use of emotional codes are presented. It is concluded that (...) the emotional codes applied to language and marketing allow effective communication, the CEs have become strategies that companies use to convince, persuade and retain customers, through the effective communication of the subconscious knowledge of the emotions that the human being surfaces and the emotional code that it produces in the search for being. CEs have similar results despite globalization and the interaction of other cultures, and they adapt to the circumstances in which they operate in a technological, cultural and social environment. The EC are classified according to the triune brain; From the point of view of emotions, ECs allow us to feel, to let ourselves be carried away by impulses, by emotions, by experiences that cause us joy or, on the contrary, pain, whether they drive us or not. The EC represent the human being, emotional, with inheritances and stories that frame the needs, desires, whims, fears, experiences and fantasies. (shrink)

O CRIME DE LAVAGEM DE DINHEIRO NAS ORGANIZAÇÕES RELIGIOSAS.

O jogo é entendido enquanto um fenômeno complexo, em que a ação do jogador se caracteriza pela eticidade, uma vez que, além de expressar sua subjetividade, visa à boa vida (no caso do jogo, o prazer e a vitória). Assim, o caráter ético da ação do jogador se constitui em um ambiente de jogo, local que a imprevisibilidade, a dinâmica e as novas organizações estão presentes. Dessa maneira, faz parte da função do jogador compreender o ambiente em que ele se (...) encontra, ou seja, entender como as organizações do jogo ocorrem. De modo semelhante, o conceito chamado de “absurdo”, criado por Albert Camus, filósofo franco-argelino, assemelha-se a essa demanda do entendimento do meio em que se vive, ao exaltar a tomada de consciência. Como consequência, segundo ele, o único movimento possível, posterior à compreensão do absurdo é a revolta, ação pautada na expressão do sujeito, com vistas à justiça, à coletividade e à unidade, baseando-se em limites que não devem ser ultrapassados. A partir disso, portanto, pensa-se na possibilidade de entender o jogador enquanto um homem revoltado no jogo, buscando, dada a identificação do meio em que se está, o sucesso de sua equipe, através de suas ações. (shrink)

Hipólito Unanue. Bartolomé Herrera. Manuel González Prada. José de la Riva Agüero. José Carlos Mariátegui César Vallejo.

This study examines how businesses manage uncertainty through a combination of emerging technologies, organizational agility, and sustainability practices. Using an integrative literature review and case studies across global regions, the research identifies strategies that enhance decision-making and resilience in volatile environments. The study draws on Dynamic Capabilities Theory and Organisational Information Processing Theory to analyze how companies leverage Big Data, Artificial Intelligence (AI), and Blockchain to navigate uncertainty while ensuring ethical standards. Key findings suggest that firms that adopt flexible organizational (...) structures and sustainable technologies are better positioned to mitigate risks and maintain a competitive edge. Ethical considerations, such as managing algorithmic biases and data privacy, are highlighted as essential for the responsible adoption of these technologies. The study concludes that integrating agility, advanced data analytics, and sustainability not only enhances organizational resilience but also offers long-term strategic advantages. The research provides practical recommendations for business leaders and proposes future research directions focused on SMEs and the ethical implications of digital transformation. (shrink)

Este artículo aborda el estudio de algunos de los problemas que presenta la religión en las democracias contemporáneas y, más específicamente, las aporías políticas que suscita la participación de los creyentes en el debate público. Para desarrollar la temática, el texto se divide en dos partes: en la primera, se exponen las objeciones que, en las democracias seculares se le presentan al discurso religioso. En la segunda, se identifican algunos tópicos teóricos que deben asumir los creyentes si quieren que dicho (...) discurso alcance eficacia pública y sea recibido como un aporte a la deliberación democrática y a la construcción de una ciudadanía plural. (shrink)

In this essay we consider the possibility of knowledge being transferred or transmitted via testimony. Initially, we present an introduction to the epistemology of testimony, by indicating their origin in a tradition that has John Locke, David Hume and Thomas Reid as their representatives. We present a version of the non-reductionist thesis. We show that the non-reductionist about knowledge must request from the speaker a testimonial epistemic performance that is truth conductive, as well as intellectual integrity from the listener.

Me, Gabriel Vacariu, professor at Department of Theoretical Philosophy, Faculty of Philosophy, Bucharest University, Romania, I declare that I have had the worst promotion during my entire career at this department even if I have had the best CV during my career (since 1998). With this memorandum, I want to find the criteria for the promotion at my department and faculty (from Bucharest University). From what I know, my promotion depends on the will of the chief of the department (...) and of my colleagues. If my colleagues do not want my promotion, I will never be promoted! I emphasize that, in relationship with my colleagues, I have had the worst promotion even if I have had the best CV. (shrink)

Gabriel Vacariu (2020) Unbelievable similarities - selected authors (Sean Carroll, Frank Wilczek, Carlo Rovelli, Kastner, Kauffman et all, Lee Somlin, Markus Gabriel) from much bigger manuscript (Gabriel Vacariu, (June 2020 to 2014) The UNBELIEVABLE SIMILARITIES between the ideas of some people (2011-2016) and my ideas (2002-2008) in physics (quantum mechanics, cosmology), cognitive neuroscience, philosophy of mind, and philosophy (this manuscript would require a REVOLUTION in international academy environment!) here -/- (During last 4 years, I have sent this (...) updated manuscript to thousands of people from many countries in each year! They have no chances!!!) All my main ideas (the mind-brain problem, main problems of cognitive science and quantum mechanics, Einstein’s relativity vs. quantum mechanics, etc.) from my Springer’s book (2016) can be found in my PhD thesis (2007), UNSW (Sydney, Australia, officially posted on university’s website, FREE, by the university’s Staff in 2007) . (shrink)

La voz humana es un fenómeno ampliamente estudiado desde una gran variedad de disciplinas, desde las especialidades de la medicina hasta las artes. Aunque esta situación resulta enriquecedora, la multiplicidad de perspectivas ha conspirado contra la formulación de una concepción única de la voz y de un sistema lógico que pueda ayudar a entender los fenómenos asociados con ella en términos más generales, enfatizando continuidades y relaciones en lugar de requerir cada vez una definición del objeto de estudio de acuerdo (...) con las herramientas conceptuales y las metodologías de cada disciplina. La semeiotica de Peirce ofrece una alternativa a esta fragmentación de los estudios de la voz, especialmente a través de su taxonomía de signos relacionada con las categorías faneroscópicas. El nonágono semiótico es un modelo operativo que, adoptando la forma de un ícono diagramático, ayuda a aplicar las categorías peirceanas al análisis de conceptos, objetos o disciplinas en general. Con el nonágono semiótico como herramienta metodológica, este artículo ofrece una forma de analizar, describir y categorizar de acuerdo con criterios lógicos los múltiples usos de la voz humana. Se espera que las relaciones que revela entre usos radicalmente diferentes de la voz ayuden a reducir la redundancia entre disciplinas y a proveer nuevas direcciones para la investigación en otras áreas, así también como para cubrir potenciales necesidades pedagógicas y analíticas en las artes y otras disciplinas. (shrink)

(2018) Gabriel Vacariu (Philosophy, University of Bucharest) 92018), ‘Section July 2018: UNBELIEVABLE similar ideas with my ideas (2002-2008) of these authors: Oreste M. Fiocco (forthcoming); Baptiste Le Bihan (University of Geneva, forthcoming); Antonella Mallozzi (The Graduate Center – CUNY, forthcoming in Synthese, penultimate draft); Erik C. Banks (Wright State University, 2014); Sami Pihlström (2009) -/- [I investigated these works in July 2018: In this section, I will include only paragraphs from various articles or books written by different persons. These (...) paragraphs contain ideas that are UNBELIEVABLE similar to my ideas published between 2002-2008. I mention that there are other ideas very similar to my ideas (especially in books) but I did not have the interest and time of reading word by word these works.] -/- . (shrink)

CONTENIDO: El entierro - El padre - Otro padre - La montaña mágica - Los amigos - Bucarest - En Sumapáz - Yolanda - Cali - Medellín - Freud - Doctorado Honoris Causa - Los derechos humanos - La angustia.

Se hace en este ensayo una propuesta de interpretación para la versión específica del pragmatismo propuesta por Peirce, ya que su conexión con el realismo tiene ciertas consecuencias que podrían llevar una revisión radical de la frecuente adscripción de Peirce o bien al holismo de la confirm..

This book provides an up to date, high-level exchange on God in a uniquely productive style. Readers witness a contemporary version of a classic debate, as two professional philosophers seek to learn from each other while making their cases for their distinct positions. In their dialogue, Joshua Rasmussen and Felipe Leon examine classical and cutting-edge arguments for and against a theistic explanation of general features of reality. The book also provides original lines of thought based on the authors’ own (...) contributions to the field, and offers a productive and innovative inquiry into on one of the biggest questions people ask: what is the ultimate explanation of things? (shrink)

Since 2015, incredible many have published UNBELIEVABLE similar ideas to my ideas published between 2002-2008!!! There were others who published UNBELIEVABLE similar ideas to my ideas even earlier (since 2008, in general), but the number has an incredible jump after 2014. Why? In 2014, I have sent emails to thousands of people (many countries, many domains (Physics, Philosophy, and Cognitive Science)) regarding the UNBELIEVABLE similarities between my ideas (2002-2008) and Markus Gabriel’s ideas (his book from 2013). Is it this (...) a coincidence? I don’t believe so… Why so many people from so many countries from so many domains on so many topics have published UNBELIEVALBE similar ideas to my ideas (2002-2008 and later)? Because I have changed EVERYTHING! (shrink)

Mentionez ca, in raport cu colegii mei, la acest departament si facultate, eu am avut am avut cea mai slaba promovarea de-a lungul carierei mele, desi CVul meu a fost, inca de la inceput, cel mai bun raportat la cei din generatia mea sau apropiati de generatia mea. La ora actuala, raportat la criteriile INTERNATIONALE, CVul meu este cel mai bun de la aceasta facultate.

El artículo analiza el concepto de mal radical de Kant y sostiene que su explicación del mal utiliza un modelo reconstructivo que niega la atribución de los modelos de adicción o del mal hábito. Se critica la tesis de la “revolución en la disposición moral fundamental”, primero, porque Kant abandona el método fenomenológico-trascen- dental y, segundo, por el carácter semipelagiano de su argumentación.